Hour 1

• List the cells where histamine is predominantly found.
• Describe the role of the Mast Cell.
• Explain histamine’s function and recall what causes its release.
• List the Histamine receptor types and where each are each found.
• Summarize or give examples of symptoms in over activation of histamine receptors.
• Many of our patients are on OTC Antihistamine medications.  List their effects, positive and negative.

Hour 2

• Quote what OAS stands for.
• Define OAS and describe what happens to those with this problem.
• Recognize at what age(s) OAS occurs.
• Memorize, recognize and describe 1-5 OAS examples.
• Educate your patient on how to deal with OAS.
• Describe NFkB as a system
• Describe NFkB’s role in canonical and non-canonical pathways
• Explain what IκBα is and its potential role in downregulating inflammation

Hour 3

• Discuss how specific herbs, nutrients, and Vitamin E work to manage histamine at both a macro and microscopic level.
• Be able to describe allergic inflammation
• Discover how NSAIDs are being noted to reduce CNS diseases with inflammation and may help manage allergic disorder(s). 
• Identify what particular NSAID is naturally occurring and available to us and your patients to help them manage their allergic inflammation.  Calculate its clinical dose and avoid its lethal dose.
• List various SPMs (Specialized Proresolving Mediators)
• Describe how SPMs can control IgE production and play a potential role in the treatment of Alzheimer’s Disease.
• Relate histamine’s role in IBS (Irritable Bowel), name and synthesize the type of 2 known GI receptors involved.

Hour 1

• Indicate the immune system’s complexity as it fits into the body’s function
• Give examples of various Interleukins involved in the immunity
• List neurotransmitters, and vasoactive dilators
• Contrast TH1 and TH2 immune cells and apply a working knowledge of their clinical phenotype.

Hour 2

• Discuss signs and symptoms of anaphylaxis and current therapy.
• List the major immune cells responsible for allergic reactions
• Name the major receptor responsible for IgE sensitization, and what cells it is primarily found on.
• Summarize the meaning of WAO.
• List signs and symptoms of a typical allergic response after re-exposure to a sensitized allergen
• List different methods of allergy testing and critique their strengths and weaknesses.
• Give an example of a complicating factor that might skew an IgE(total) test result
• Apply the terms sensitivity and specificity in lab tests
• Categorize who is at risk of allergic sensitization.

Hour 3

• List 1-2 examples of research supporting IgE sensitization prevention.
• List 1-2 examples of factors which may increase risk of IgE sensitization.
• Explain the effect of smoking on IgE
• Have working knowledge of the effect of SO2 on health, and its primary source.
• Describe how and why it Ragweed is fast becoming worse of a problem throughout the US and worldwide.
• Indicate a potential sequela of Rhinoconjunctivitis and why it is meaningful to treat
• Identify and name a treatment backed by clinical evidence for Ragweed allergy and its meaning for natural therapy to be used by non-prescribing practitioners
• Describe a potential problem with medical Sublingual allergy therapy, and then defend it.
• Outline the major allergens in Ragweed.
• Give an example of co-sensitivity
• Define Pan allergen and give an example